Aprahydro 500mg

Aprahydro 500mg

Composition- Each Hard capsule contains Hydroxy-urea -500mg IP

Therapeutic Class –Antineoplastic, Cytotoxic Agent

What is Aprahydro?

It is an anti-cancer drug, it is used to treat cancers of the blood or bone marrow and solid tumors.

Uses of Aprahydro -

• Resistant Chronic Myeloid Leukemia

• Melanoma

• Recurrent and Metastatic Carcinoma of the Ovary

• Squamous cell carcinoma of the head and neck

How does Aprahydro work?

• Inhibit the ribonucleotide reductase enzyme used for cancer cell growth.

• Inhibits DNA synthesis.

• Causes Apoptosis, cancer cell death

Common side effects of Aprahydro

Nausea, vomiting, thrombopenia, fatigue, neutropenia

Serious side-effects

• Bone marrow suppression

• Infection risk

• Skin rashes and ulcers occur on long-term use

Contraindications

Not to be used in patients with prior hypersensitivity to the drug or its excipients

Precautions

To be cautiously used in –

• Renal insufficient patients

• Breastfeeding mothers

• Pregnant women

Toxicities

Hydroxyurea causes dose-dependent systemic toxicities.

• Hematological toxicities – bone marrow suppression causing thrombocytopenia, leukopenia

• Mucosal Toxicity – oral ulcers and mucositis

• Pulmonary Airway Toxicity – shortness of breath, cough, pulmonary fibrosis

• Dermatological toxicity – hyperpigmentation and skin ulcers

Warnings

It is a prescription drug to be used under medical supervision only

Important safety and monitoring information

Aprahydro is generally well tolerated, but requires regular monitoring for hematological functions, infections, renal functions and skin changes.