Dasakast 50

Dasakast- 50mg

Composition – Dasatanib 50mg IP

Therapeutic Class - Antineoplastic

What is Dasakast?

It is an anti-cancer drug used for targeted therapy for blood cancers (leukemia).

It is the first-line treatment for leukemia patients who do not respond to other drug therapies.

Uses of Dasakast

• Chronic Myeloid Leukemia

• Acute lymphoblastic leukemia

How does Dasakast Work?

It inhibits kinase enzymes as well as abnormal BCR-ABL proteins

Slows down or stops the cancer cell growth

Common Side Effects

• Fluid retention

• Lowering of blood count

• Nausea

• Diarrhea

• Skin ulcers and rashes

Serious Side-Effects

• Risk of cardiac arrhythmia

• Bone marrow suppression

• Pulmonary Arterial Hypertension

Contraindications

Not to be used in patients-

• Hypersensitivity or allergic reaction to the drug or its excipients.

• Breastfeeding mothers

• Pregnant women

Precautions

To be cautiously used in patients with –

• Bleeding disorder

• Cardiovascular diseases

• Hepatic, renal impairment

• Recent surgery or wound

• Disorders of the stomach

Toxicities

• Bone Marrow suppression – low blood count

• Pleural effusion- shortness of breath, fluid buildup around lungs

• Hematological toxicity –bleeding risk, decreased platelet count

• Hepatotoxicity – elevated enzymes

• QT Prolongation- irregular heartbeats

Warnings

Prescription drug to be used under medical supervision

Important Safety and Monitoring Information

Dasakast requires regular monitoring for hematological functions, blood pressure, liver functions, ECG, regular monitoring of electrolytes,