Mitomycin

Mitomycin

Composition: Mitomycin 10mg

Therapeutic class: It is an Anti-neoplastic, an antibiotic

What is Mitomycin?

Mitomycin is used as an anticancer medicine against many cancers and solid tumors.

Uses of Mitomycin

• Stomach cancer

• Pancreatic cancer

• Ovarian cancer

• Breast cancer

• Uterus cancer

• Small cell lung cancer

How does Mitomycin work?

It gets attached to DNA, forms cross-links in the DNA, inhibits replication, and division, causing cancer cell death.

Common Side Effects

• Nausea

• Bone marrow suppression

• Mouth ulcers

• Alopecia

• Skin rashes

Serious Side Effects

High doses can lead to:

• Anemia

• Low platelet count

• Lung scarring

• Kidney damage

• Liver toxicity

• Shortness of breath

• Fast irregular heartbeat

Precautions

To be cautiously used in:

• Pre-existing liver disorder

• Kidney disorder

• Bleeding disorders

• Severe infection

• Elderly patients

• Mylosuppressant therapy

• Respiratory infection

• Asthma

• Anemic

Contraindications

• Not to be used if any previous allergy or hypersensitivity to Mitomycin or any excipients.

• Breastfeeding mothers

• Pregnant women

Warning:

To be used under the supervision of a medical practitioner or oncology specialist, having adequate diagnostic and monitoring facilities.

Important safety and monitoring information

Monitor-

• Total blood count

• Renal functions

• Pulmonary functions

• Hepatic functions

• Local tissue necrosis

Storage

It should be stored at 2-8 degrees Celsius, protected from light.

Administration Instructions

• To be administered as a slow IV infusion.

• Avoid IV push or rapid bolus.

• To be used immediately after reconstitution.