Abacavir & Dolutegravir & Lamivudine

Abacavir, Dolutegravir, Lamivudine

Classification: HIV medicine

What is Abacavir, Dolutegravir, and Lamivudine combination?

The combination of the drug in a fixed proportion is used for HIV-1 treatment. Used in children and young adults.

Uses

• • First-line treatment for HIV infection
• • Preventive or maintenance therapy of HIV

How does the combination work?

• • It stops viral cell multiplication and replication.
• • Reduces HIV amount in the blood

Benefits

• • Potent viral suppression to undetectable levels
• • Convenient daily dosing
• • Lowers resistance
• • Better tolerance and adherence
• • Easy convenient use
• • Improves the immune system

Common side effects

• • Headache
• • Skin rashes
• • Insomnia
• • Muscle pain
• • Joint pain
• • GIT upset
• • Fever
• • Anxiety, mood changes

Serious side effects

• • Overactive immune system
• • Hepatitis B flare
• • Severe allergy
• • Skin peeling
• • Liver toxicity
• • Severe anxiety, suicidal thoughts, and insomnia

Precautions

To be used cautiously in:

• • Elderly persons
• • Co-infection – hepatitis B
• • Renal impairment
• • Liver dysfunction
• • Cardiovascular disorders
• • Neurological disorders
• • Pregnant and breastfeeding women

Contraindications

• • Severe liver dysfunction
• • Hypersensitivity or allergy to drug components

Warnings

To be used under medical prescription. Hepatitis B co-infections may cause serious viral flare-ups; do not stop medication immediately.

Important Monitoring Considerations

Check for –

• • Lactic acidosis
• • Liver function – elevated liver enzymes
• • Viral loads (HIV, HBV)
• • Neurological conditions
• • CD4 cell count
• • Cardiovascular functions

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