Bosentan 125mg

Bosentan 125mg

Classification: Pulmonary Hypertension Medicine

Bosentan?

Bosentan used against pulmonary hypertension, is a hypertensive medicine.

Uses of Bosentan

• • Arterial hypertension
• • Ulcers in systemic sclerosis

Off-label uses

• • Thromboembolic hypertension (off-label)
• • Congenital pulmonary hypertension
• • Systemic sclerosis (Raynaud's phenomenon)

Working of Bosentan

• • It relaxes the blood vessels
• • Blocks the natural vasoconstrictor in blood
• • It dilates the blood vessels and reduces blood pressure in the lungs.

Benefits

• • Its helps the heart to pump efficiently
• • Lowers lung pressure
• • Improves blood flow
• • Improves breathing
• • Enhances exercise tolerance
• • Slows disease progression
• • Prevents ulcers in scleroderma

Common Side Effects

• • Headache
• • Flushing of the skin
• • Redness of the skin
• • Fluid retention in ankles, legs
• • Basal congestion
• • Tiredness
• • Diarrhea
• • Bronchitis
• • Muscular pain and joint pain

Serious Side Effects

• • Liver damage – increased liver enzymes
• • Dark urine, yellowish urine
• • Serious fluid retention – weight gain, leg swelling
• • Decreased sperm count

Precautions

To be cautiously used in patients with –

• • Liver disorders
• • Low blood count
• • Fluid retention
• • Cardiac failure
• • Impaired sperm production in men

Contraindications

Not to be used in patients-

• • Allergy to the drug components
• • Pregnant and breastfeeding women
• • Severe liver disorders

Warnings

Prescription drug to be used under medical supervision.

Drug Interactions

Use of Bosentan is contraindicated with:

• • Cyclosporine
• • Hormonal contraceptives
• • Antibiotics
• • Antifungals
• • Antivirals
• • Statins
• • ED medicines
• • Anticoagulants

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