Active Chemical Molecule
Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg
Composition-
Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg
Classification: HIV Medicine
Dolutegravir, Emtricitabine, Tenofovir Alafenamide?
It is widely used as a single-dose regimen against HIV infection that offers better patient compliance and a synergistic effect.
Uses
- ⢠HIV -1 infections
How does it work?
- ⢠Dolutegravir - It prevents genetic transmission into human immune cells (CD4+ T cells).
- ⢠Emtricitabine ā It inhibits viral cell multiplication.
- ⢠Tenofovir Alafenamide ā Stops the formation of viral cell copies.
Benefits
- ⢠Powerful control of HIV
- ⢠Well tolerated
- ⢠Lowers the risk of drug resistance
- ⢠Fewer side-effects
- ⢠Improves immunity
- ⢠Prevent transmission
- ⢠Prevent HIV progression
Common Side Effects
- ⢠Insomnia
- ⢠Tiredness
- ⢠Headache
- ⢠Increased weight
- ⢠Dermatological side effects
- ⢠Nausea
- ⢠Diarrhea
- ⢠High levels of cholesterol
Serious Side Effects
- ⢠Liver dysfunction
- ⢠Lactic acidosis
- ⢠Increased blood glucose
- ⢠Kidney dysfunctions
- ⢠Neurological side effects ā depression / suicidal thoughts
Precautions
To be used cautiously in
- ⢠People with diabetes
- ⢠Liver disorders
- ⢠Mental health
- ⢠Pregnant women
Drug Interactions
- ⢠Antacids
- ⢠Rifampicin
- ⢠Phenytoin
- ⢠Efavirenz
- ⢠Barbiturates
- ⢠Metformin
- ⢠Iron/calcium supplements
Contraindications
- ⢠Severe liver dysfunction
- ⢠Severe renal impairment
- ⢠Hypersensitivity or allergy to drug components
- ⢠Children under 4 weeks or less than 3kg
Warnings
- ⢠To be used under medical prescription
- ⢠Stop treatment by tapering the dose in Hepatitis co-infections
Important Monitoring Considerations
Check for ā
- ⢠Liver function ā elevated liver enzymes
- ⢠Viral loads (HIV, HBV)
- ⢠Neurological conditions
- ⢠CD4 cell count
- ⢠Renal functions
- ⢠Blood glucose
- ⢠Weight
Gandhi Medicos ā Global Standard HIV Medicines
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Formulations based on "Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg" (0)
No formulations are currently registered using this composition.
