Fulvestrant 250mg

Fulvestrant

Classification: Anticancer Medicine

Fulvestrant?

It is an anticancer medicine widely used for breast cancer in post-menopausal women.

Uses

• • HER-2 positive breast cancer
• • HER-2 negative breast cancer
• • Breast cancer that is resistant to endocrine therapy

How does Fulvestrant work?

• • Selective Estrogen Receptor Antagonist.
• • It inhibits the estrogen hormone, which causes cancer cells to grow.
• • Stops cancer cell growth
• • Shrinks the tumor.

Benefits

• • As a preferred second-line option.
• • Longer progression–free survival
• • Directly downregulates the receptor for complete blockade
• • Has better tolerance and a favorable safety profile.

Precautions

Carefully administer to patients with:

• • Blood disorders
• • Hypersensitive individuals
• • Hepatic impairment
• • Children, pregnant or lactating mothers
• • Elderly patients who are at risk of osteoporosis.
• • Vitamin D or Calcium deficiency

Adverse Drug Effects

• • Risk of bleeding
• • Sore throat
• • Mouth sores
• • Upset stomach,
• • Nausea,
• • Loss of appetite
• • Headache,
• • Tiredness
• • Flushing or redness of the skin at the site of injection.

Serious Side Effects

• • Hepatotoxicity – yellow coloration of urine, jaundice, hepatitis
• • Pulmonary embolism, blood clots
• • Severe necrosis
• • Gastrointestinal perforation, bleeding
• • Fracture or risk of bone demineralization

Important Safety and Monitoring Information

To monitor regularly during the therapy

• • Total blood count
• • Hepatic functions
• • Kidney functions
• • Risks of bleeding
• • Thromboembolic events
• • Local tissue necrosis

Contraindications

• • Allergy or hypersensitivity to drug components
• • Breastfeeding mothers
• • Pregnant women

Warning

To be used under the medical supervision of an oncology specialist.

Storage

It is to be stored at 2-8 degrees Celsius, protected from light.

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