Imatinib
Imatinib
Classification: Anticancer
Imatinib Mesylate?
It is a targeted anticancer treatment used against various blood cancers and bone marrow cancers.
Uses of Imatinib
- • Chronic myeloid leukemia
- • Myeloproliferative disease
- • Lymphoblastic leukemia
- • Gastrointestinal tumors
- • Philadelphia Chromosome–Positive leukemia
How Does Imatinib Work?
It blocks cell multiplication and division. Blocks rapidly dividing cells.
Common Side Effects
- • Fluid retention
- • Skin rash
- • Headache
- • Indigestion - nausea, diarrhea
- • Abdominal pain
- • Loss of appetite
- • Muscle pain, joint pain
- • Anemia
Serious Side Effects
- • Hepatic-toxicity – jaundice, hepatitis
- • Heart issues – irregular heartbeat, arrhythmias
- • Shortness of breath
- • Bone marrow suppression
- • Perforation in the gastrointestinal wall
- • Severe rash or peeling of the skin
Precautions
To be used cautiously in patients with –
- • Kidney disorders
- • Liver disorders
- • Cardiac insufficiencies
- • Thyroid disease
Contraindications
- • Allergy or hypersensitivity to Imatinib or its components
- • Breastfeeding mothers
- • Pregnant women
- • Congestive heart failure
Important Safety and Monitoring Information
Regularly monitor-
- • Liver functions
- • Blood count
- • Weight and swelling in the body
- • Pleural/pericardial effusion or pulmonary edema
- • Cardiac functions – ECG/ECHO
- • Thyroid functions – TSH/T4 Levels
Important Drug Interactions
Monitor closely or consider dose reduction when co-administered with:
- • Antifungals
- • Macrolides
- • Warfarin
- • Statins
- • Rifampin-like drugs
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Formulations based on "Imatinib" (4)
Veenat 100
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Imatikast (Imatinib 100 mg)
Imatinib
Imatinib 100 mg tablet treats specific types of acute cancers like gastrointestinal stromal tumors, chronic myeloid leukemia, myeloproliferative disease, lymphoblastic leukemia, etc. This medicatio...
Imatikast Tablet 400mg
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Imatikast (Imatinib 400 mg), the indigenous drug, is used for patients with different types of blood cancer caused by the irregular growth of white blood cells (WBCs). Imatikast 400-800 mg (Imatini...
Veenat 400 Tablet
Imatinib
Veenat 400 (Imatinib), the indigenous drug, is used for patients with different types of blood cancer caused due to irregular growth of white blood cells (WBCs). It hinders the growth of these abno...