Imatinib

Imatinib

Classification: Anticancer

Imatinib Mesylate?

It is a targeted anticancer treatment used against various blood cancers and bone marrow cancers.

Uses of Imatinib

• • Chronic myeloid leukemia
• • Myeloproliferative disease
• • Lymphoblastic leukemia
• • Gastrointestinal tumors
• • Philadelphia Chromosome–Positive leukemia

How Does Imatinib Work?

It blocks cell multiplication and division. Blocks rapidly dividing cells.

Common Side Effects

• • Fluid retention
• • Skin rash
• • Headache
• • Indigestion - nausea, diarrhea
• • Abdominal pain
• • Loss of appetite
• • Muscle pain, joint pain
• • Anemia

Serious Side Effects

• • Hepatic-toxicity – jaundice, hepatitis
• • Heart issues – irregular heartbeat, arrhythmias
• • Shortness of breath
• • Bone marrow suppression
• • Perforation in the gastrointestinal wall
• • Severe rash or peeling of the skin

Precautions

To be used cautiously in patients with –

• • Kidney disorders
• • Liver disorders
• • Cardiac insufficiencies
• • Thyroid disease

Contraindications

• • Allergy or hypersensitivity to Imatinib or its components
• • Breastfeeding mothers
• • Pregnant women
• • Congestive heart failure

Important Safety and Monitoring Information

Regularly monitor-

• • Liver functions
• • Blood count
• • Weight and swelling in the body
• • Pleural/pericardial effusion or pulmonary edema
• • Cardiac functions – ECG/ECHO
• • Thyroid functions – TSH/T4 Levels

Important Drug Interactions

Monitor closely or consider dose reduction when co-administered with:

• • Antifungals
• • Macrolides
• • Warfarin
• • Statins
• • Rifampin-like drugs

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