Lamivudine 150mg + Zidovudine 300mg
Lamivudine 150mg + Zidovudine 300mg
Classification: HIV Medicine
Lamivudine and Zidovudine?
The fixed doses of lamivudine and zidovudine form a highly active antiretroviral therapy against HIV.
Uses
- • HIV infection
- • Post-exposure prophylaxis
- • To prevent HIV transmission to the child during pregnancy
Working of the Lamivudine and Zidovudine Combination
- • Inhibits the multiplication of HIV cells
- • Reduces HIV cell count
Benefits
- • Reduces viral load
- • Improves immunity
- • Delays disease progression
- • Reduces the risk of transmission
- • Reduces co-infections
- • Increases CD4+ count
- • Can be used in children
Common Side Effects
- • Nasal congestion
- • Cough
- • Headache
- • Stomach pain
- • Indigestion – diarrhea, nausea
- • Tiredness
- • Muscle pain, joint pain
- • Sore throat
Serious Side Effects
- • Bone marrow suppression
- • Hepatomegaly – jaundice, yellowish urine
- • Lactic acidosis – breathing problems
- • Liver inflammation
- • Inflammation of the pancreas in children
- • Risk of severe infections
- • Allergic reaction
- • Myopathy
Precautions
To be used cautiously in –
- • Liver diseases
- • Kidney impairment
- • Co-infections (Hepatitis B)
- • Pregnant and lactating women
Contraindications
- • Allergy to drug components
- • Severe liver dysfunction
- • Bleeding disorders
- • Low platelet count
- • Alcohol abuse
Warnings
To be used under medical prescription.
Discontinuing immediately in Hepatitis B patients may cause serious hepatitis flare-ups.
Should not be used as monotherapy for HIV treatment.
Important Monitoring Considerations
Check for –
- • Lactic acidosis
- • Liver function – elevated liver enzymes
- • Viral loads (HIV, HBV)
- • Pancreatitis
- • Co-infections
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Formulations based on "Lamivudine 150mg + Zidovudine 300mg" (1)
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