Methotrexate 50mg/2ml

Methotrexate - 50mg

Classification – Anticancer Medicine

What is Methotrexate?

It is an anticancer medicine that has multiple uses. It is used against many cancers and autoimmune diseases.

Uses of Methotrexate

• • Blood cancers
• • Lymphomas
• • Bladder cancer
• • Lung cancers
• • Sarcomas
• • Arthritis
• • Psoriatic arthritis
• • Lupus erythematosus
• • Crohn’s disease

Common Side Effects

• • Nausea
• • Vomiting
• • Reduced appetite
• • Tiredness
• • Mouth ulcers
• • Diarrhea
• • Photosensitivity
• • Skin rashes

Serious Side Effects

• • Bone marrow suppression
• • Liver dysfunction
• • Lung toxicity
• • Kidney toxicity
• • Headache
• • Dizziness
• • Seizure

How Does Methotrexate Work?

Methotrexate inhibits several nucleotide synthesis enzymes:

• • Inhibiting inflammation – used in arthritis
• • Cell division – used in cancer treatment

Contraindication

• • Its use is contraindicated in patients who have an allergy to methotrexate or a history of hypersensitivity to any excipients.
• • Patients with impaired renal and hepatic functions.

Toxicities

• • Bone Marrow Suppression
• • Hepato-toxicity
• • Nephrotoxicity
• • Pulmonary Toxicity
• • Neurotoxicity related to high doses
• • Gastrointestinal toxicity

Precautions

• • To be used cautiously in renal insufficiency and impaired hepatology function.
• • Should not be used in pregnant and lactating mothers, as it may cause teratogenic effects.

Warnings

Should be given under the supervision of an oncologist or a medical practitioner. Take folic acid supplementation to reduce side effects.

Important Monitoring Instruction

Access for mouth ulcers, liver tests, lung functions, and skin infections.

• • Liver functions
• • Lung functions

Drug Interactions

Always avoid NSAIDs, alcohol, and live vaccines.

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