Mycophenolic acid

Mycophenolic Acid

Classification: Organ Transplant Medicine

Mycophenolic Acid?

It is immune-suppressant medicine to reduce the organ rejection during transplant.

Mycophenolic Acid Oral Uses

• • Prophylaxis for organ transplant.
• • Post-transplant therapy – Kidney transplant, Liver transplant, Heart transplant
• • Autoimmune diseases- Psoriasis, SLE (off-label)

Working of Mycophenolic Acid?

• • It down-regulates the activity of B cells and T cells.
• • Suppress the immune system.
• • Helps prevent rejection of the new organ when transplanted in the body.
• • Reduces anaphylactic immune response.

Common Side Effects

• • Skin rashes
• • Risk of infection
• • Low blood count
• • Low platelets
• • Anemia

Serious Side Effects

• • Risk of severe infection
• • Bleeding – gastrointestinal perforation and bleeding
• • Inflammation in the colon
• • Risk of cancers, lymphomas, and skin cancers
• • Risk of brain infection

Benefits

• • More selective action, target immune cells.
• • Do not harm other cells.
• • Reduces the need for steroids
• • Minimizes the risk of rejection
• • Maintain immune tolerance
• • Supports long-term graft survival

Precautions

To be used cautiously in

• • Kidney impairment
• • Bleeding disorders
• • Active infection
• • Underline cancer
• • Leukemia
• • Elderly patients

Safety Instructions

• • Maintain contraception during the treatment.
• • Avoid live vaccines (MMR, Varicella) due to a compromised immune system.

Contraindications

• • Should not be used in pregnant women and breastfeeding mothers.
• • Hypersensitivity or allergy to drug components.

Warnings

To be used under medical prescription.

Drug Interactions

• • Antiviral
• • Antacids
• • Antibiotics
• • And other immune suppressants

Important Monitoring Considerations

Monitor for –

• • Total blood count
• • Liver and kidney functions

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