Sofosbuvir + Ledipasvir

Classification: Hepatitis C Medicine

Sofosbuvir + Ledipasvir combination –

• Trusted combination of antiviral drugs effective against Hepatitis C genotypes 1,4,5,6.
• Can be used in cirrhosis (both compensated and decompensated).
• Can be used in HIV co-infections.
• In children > 3 years
• Can be used post-liver transplant

Uses

• Chronic Hepatitis C
• HCV-HIV co-infections

Working of Sofosbuvir and Ledipasvir

It inhibits viral cell replication by inhibiting two different protein polymerases, offering potent viral suppression.

Benefits

• Short-term treatment
• High cure rates
• Low resistance risk
• Well tolerated
• Reduces liver damage

Common Side Effects

• Nausea
• Dizziness
• Headache
• Digestive issues
• Tiredness
• Muscle pain
• Joint pain

Serious Side Effects

• Severe Bradycardia (when taken with amiodarone)
• Causes Hepatitis B reactivation
• Severe liver failure
• Severe anemia upon use with ribavirin
• Depression, mood swings, and confusion

Precautions

To be used cautiously in patients with:

• Kidney disorders
• Cardiac disorders
• Liver disorder
• Hepatitis B co-infections
• HIV co-infection
• When used with ribavirin and amiodarone

Contraindications

• Allergy or hypersensitivity to drug components
• Breastfeeding mothers
• Pregnant women

Should not be used with Amiodarone, Antacids, and Proton pump inhibitors.

Warning

To be taken under the instructions of the doctor.

Important Safety and Monitoring Information

• Regular monitoring of hepatic, renal, and cardiac functions
• Co-infections
• Neuropsychiatric adverse reactions
• Drug interactions – Ribavirin and Amiodarone
• Not to be used alone for HCV infections

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