Tacrolimus 1mg

Tacrolimus 1mg

Classification – Organ Transplant Medicine

What is Tacrolimus?

Tacrolimus is an organ transplant medicine, widely used for post-transplant care and prophylaxis of organ rejection.

Best-selling Transplant Medicine – Xgraf -1

Uses of Tacrolimus

• • Prophylaxis for organ transplant
• • Post-transplant therapy
• • Kidney transplant
• • Liver transplant
• • Heart transplant

Working of Tacrolimus

It suppresses the activity of T cells and lowers the immune response.

Accepts the organ transplants.

Benefits

• • Faster onset
• • Potent immune-suppression
• • Long-term graft survival

Common Side Effects

• • Increases creatinine
• • Skin rashes
• • Headache
• • GIT upset
• • Nausea
• • Diarrhea
• • High calcium levels
• • Low potassium levels
• • Tiredness

Serious Side Effects

• • Renal toxicity
• • Severe infections
• • Seizures, encephalopathy
• • Bone marrow suppression
• • Metabolic dysfunctions
• • Cardiovascular side effects – arrhythmias, high blood pressure
• • Lymph proliferative disorder (PTLD)

Precautions

To be used cautiously in:

• • Elderly Patients
• • Bleeding disorders
• • Liver disorders
• • Kidney diseases
• • Active infections - HIV, Hepatitis
• • Diabetics
• • Hypertension patients
• • Neurological disorders

Safety Instructions

• • Maintain contraception during the treatment
• • Avoid live vaccines (MMR, Varicella) due to a compromised immune system

Contraindications

• • Pregnant women and breastfeeding mothers
• • Hypersensitivity or allergic reaction to the drug or its excipients

Warnings

To be used under medical prescription only.

Drug Interactions

• • Antivirals
• • Antibiotics
• • TB medicines
• • Other immune suppressants
• • Cardiovascular drugs – calcium channel blockers
• • Antifungals
• • Grapefruit juice

Important Monitoring Considerations

• • Total blood count
• • Liver and kidney functions
• • Neurological functions
• • Blood pressure, blood glucose
• • Cardiac functions
• • Dose monitoring is required

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