Ketoconazole 200 Mg

Ketoconazole 200 Mg

Classification: Antifungal Medicine

Ketoconazole- 200 mg?

It is used for various systemic fungal infections and yeast infections.

Uses

• • Systemic fungal infections
• • Mucocutaneous candidiasis
• • Tinea infections
• • Dermatitis
• • Deep-seated fungal infections
• • Psoriasis, caused by a fungal infection

Working of Ketoconazole

• • Breaks the fungal cell membrane integrity.
• • Causes fungal cell death.

Common Side Effects

• • Nausea
• • Vomiting
• • Diarrhea
• • Fatigue
• • Stomach ache

Severe Side Effects

• • Painful skin rashes
• • Menstrual irregularities
• • Gynecomastia
• • Sexual dysfunction
• • Arrhythmia
• • Suppression of the adrenal glands
• • Liver dysfunction
• • Jaundice
• • Electrolyte imbalance

Toxicities

• • Liver toxicity
• • Adrenal insufficiency
• • Arrhythmia
• • QT prolongation

Precautions

To be used cautiously in patients with

• • Any heart problem
• • Liver disorders
• • Alcohol abuse
• • Achlorhydra

Contraindications

Not to be used in patients –

• • Hypersensitive or allergic to the drug composition.
• • Breastfeeding mothers
• • Pregnant women

Warning

To be used under medical prescription only

Important Safety and Monitoring Information

Regularly monitor –

• • Liver function
• • Heart rhythms
• • Hormonal functions

Drug Interactions

Ketoconazole should be used with extreme caution with

• • Cholesterol medicines - statins, fibrates
• • Anticoagulants - Warfarin, Heparins
• • Cardiovascular drugs - beta blockers, calcium channel blocker
• • Antihypertensive - diuretics, ACE inhibitors
• • Immunosuppressants - corticosteroids
• • HIV - DDA
• • Antipsychotics - antidepressants

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